Hepatitis C virus-associated membranoproliferative glomerulonephritis in renal allografts.

Rituximab therapy for hepatitis C virus‐associated cryoglobulinemic membranoproliferative glomerulonephritis

Membranoproliferative glomerulonephritis associated with mixed cryoglobulinemia is the most common form of kidney disease observed in relation to hepatitis C virus (HCV) infection. Rituximab, a monoclonal antibody against CD20, is an effective treatment for severe and/or refractory HCV-related vasculitis and may evade the need for dialysis as in our patient.

Hepatitis C Virus Associated Glomerulonephritis

Rituximab induces regression of hepatitis C virus-related membranoproliferative glomerulonephritis in a renal allograft.

Hepatitis C virus (HCV) infection complicates clinical outcome in liver and renal allografts [1]. Besides its important contribution to chronic liver disease, HCV infection is also a relevant cause of de novo immunemediated glomerulonephritis in both kidney and liver transplantation [2,3]. It has been shown that the development of de novo membranous and especially membranoproliferative glomerul...

Delayed spontaneous resolution of nephrotic syndrome in a patient with hepatitis C virus-associated membranoproliferative glomerulonephritis

Treatment with antiviral and/or immunosuppressive therapy is considered the standard care in patients with hepatitis C virus (HCV)-associated membranoproliferative glomerulonephritis (MPGN). However, even with an adequate therapy, a favourable response is not always guaranteed. In patients with HCV-associated MPGN, a delayed spontaneous remission of nephrotic syndrome is rare. We present here o...

Renal biopsy in a patient with haemophilia A and cryoglobulinaemic membranoproliferative glomerulonephritis associated with hepatitis C virus infection

A renal biopsy was performed in a 47-year-old man with haemophilia A. Thirty minutes after administration of an intravenous bolus of 4000 units of recombinant factor VIII, which increased the activity to 74-91%, a needle renal biopsy was successfully performed, followed by administration of 3000 units of factor VIII in the evening, and then the subsequent morning and evening. The patient was di...